Fast and reliable 3D analysis of biological samples

This is more than just microscopy — this is a revolutionary system of cutting-edge tools and technologies for next-generation 3D histology.

We are enabling the dimensional shift from 2D to 3D tissue histology, developing tissue clearing methods, assays, imaging technology, machine learning-enabled data processing tools and novel methods for big data statistical analysis of spatial anatomy.

Increase access to the intricate 3D structure of the brain and other complex organs with our services

Experts in tissue clearing and staining methods

Light sheet imaging on ZEISS Lightsheet Z.1 and Lightsheet 7 microscopes using our Mesoscale imaging System™

Pipeline for computational 3D reconstruction

Machine learning-based image analysis

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Imagine entire 3D cell cultures which preserve structural integrity by combining with tissue clearing methods

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Explore brain-wide neuronal activity with the Translucence Neuronal Activity Tissue Clearing Kit

Use our validated antibodies to measure cFos and Npas4, providing rich, detailed insights into systems-level activity.

The Translucence Neuronal Activity Tissue Clearing Kit is an ideal solution for next-generation 3D histology, making it the go-to option for researchers looking to streamline their processes.

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Ready to Embark on Your Pathway to a Streamlined, Reliable, and User-Friendly Tissue Clearing Workflow?

The Universal Tissue Clearing Kit provides a robust solution for all your tissue clearing needs.

Go deep with our Mesoscale Imaging System™

We developed the Mesoscale Imaging System, which makes the ZEISS Lightsheet Z.1 and Lightsheet 7 microscopes compatible with the high refractive index solutions used in iDISCO+ and other tissue clearing methods.

The system’s components exploit the superior optics of the ZEISS Lightsheet Z.1 and Lightsheet 7 microscopes and tune them for cleared tissue.

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Our services

Whole-brain assays

neuronal activity



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Custom services


tissue imaging

tissue quantification

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Latest research and news

November 29, 2023

Translucence Tissue Clearing Kits– Achieve Expert-Level Clearing And Staining In Your Own Lab

No tissue clearing experience? No problem. Translucence Biosystems is excited to announce the release of our new kit and reagent products that enable researchers to achieve expert-level tissue clearing and staining in their own labs.
Angela Prvulovic
November 16, 2023

Highlights from the 2023 Society for Neuroscience Meeting

At the recent Society for Neuroscience Meeting, we presented our tissue clearing techniques for AI-powered brain-wide measurement of amyloid plaques and plaque-associated microglia (PAMs), our software and reagents for measuring neuronal activity, as well as debuted our Clearly Delicious™️ Gummy Brains.
Angela Prvulovic
June 15, 2023

Highlights from the 9th Annual BRAIN Initiative Meeting

Translucence Biosystems recently participated in the 9th Annual BRAIN Initiative Meeting: Open Science, New Tools! The conference, held on June 12-13, 2023, aimed to foster a dynamic and collaborative research community through interactions among like-minded scientists who study the brain.
Angela Prvulovic

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