The Translucence Neuronal Activity Tissue Clearing Kit provides a simple solution for simultaneous measurement of cFos and Npas4 throughout the brain, enabling cellular-resolution monitoring of recent neuronal activity-dependent signal transduction. The Translucence Neuronal Activity Tissue Clearing Kit is an ideal solution for next-generation 3D histology, making it the go-to option for researchers looking to streamline their processes.
Our Neuronal Activity Tissue Clearing Kit empowers you to capture activity patterns across the entire brain by measuring the expression of immediate-early genes (IEGs) Npas4 and cFos at single-cell resolution.
While cFos is widely used as a marker of neuronal activity, its expression is also associated with other signaling pathways, such as cAMP elevations, neurotrophins, and other paracrine factors, which reduces its specificity as a marker of pure neuronal activity. In contrast, Npas4 is precisely regulated by Ca2+-dependent signaling downstream of neuronal activity.
Compared to traditional methods, the Translucence Kit offers a more efficient, reliable, and streamlined approach. It eliminates the need for complicated and unreliable processes, providing researchers with the simplicity they need to achieve precise and accurate measurements.
Reagents and Disposables for 5 Whole Mouse Brains:
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Our Translucence Tissue Clearing Kit offers a base kit option without Npas4 antibodies, allowing you to use your own antibodies.
Become an early-access user and help us shape the future of neuronal activity research. Early-access users will receive a 30% discount in return for sharing their valuable insights with our team. Inquire about our base kit via email email@example.com or just fill in the form.