Highlights from the 9th Annual BRAIN Initiative Meeting

Angela Prvulovic
June 15, 2023

Translucence Biosystems recently participated in the 9th Annual BRAIN Initiative Meeting Open Science, New Tools! The conference, held on June 12-13, 2023, aimed to foster a dynamic and collaborative research community through interactions among like-minded scientists who study the brain.

During the event, we presented our latest software and products, which are supported by our Phase 2 SBIR funding from NIMH and the BRAIN Initiative. Our poster, titled "Stitchy Software and Reagent Kits for Brain-Wide Cellular Resolution Snapshots of Neuronal Activity With Npas4 and cFos", details our newly-released software, Stitchy, and our iDISCO-based Neuronal Activity Tissue Clearing Kits.

Stitchy is a user-friendly standalone software tool developed for tiling and stitching terabyte-scale light sheet images. Designed to run on a standard desktop computer, Stitchy supports file formats from the ZEISS Lightsheet Z.1 and 7, as well as LaVision/Miltenyi Ultramicroscope II and Blaze. Its intuitive user interface allows for easy cropping of stitch areas, selection of auto-alignment parameters, hand-curated tiling, instant previews, and selection of the output resolution and orientation. By avoiding proprietary intermediate formats, Stitchy significantly increases stitching speed, streamlining your light sheet stitching workflow.

To expand our ecosystem of tissue-clearing tools, we introduced the Translucence Neuronal Activity Tissue Clearing Kits. These kits offer a convenient entry point into iDISCO-based brain clearing. With the included cFos and Npas4 antibodies, researchers can obtain information-rich, brain-wide cellular-resolution snapshots of recent changes in neuronal activity.

Visit our product pages to discover more about our stitching software, Stitchy™ and our latest addition, the Translucence Neuronal Activity Tissue Clearing Kit. To view our poster presented at the 9th Annual BRAIN Initiative Meeting, access the PDF here.

We also participated in the 2023 Show Us Your BRAINs! Photo & Video Contest. Our photo submission, titled "Arteries - A Brain Imaged with Heart!," was chosen as a finalist in the public voting round. Congratulations to the top three photo and video winners and all the participants who shared their incredible work. Browse all the submissions on The BRAIN Initiative's Show Us Your BRAINs! Photo & Video Contest website here.

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