On the forefront of 3D histology | Translucence Biosystems featured in CALIT2’s Interface Magazine

by Damian Wheeler
June 7, 2021

The California Institute for Telecommunications and Information Technology at the University of California, Irvine Fall 2019 issue covers transformational tools. The article features the Mesoscale Imaging System™, developed by then Graduate Student in the dual M.D./Ph.D. program at University of California, Irvine, Ricardo Azevedo and Associate Professor, Sunil Gandhi, Ph.D.

The chamber was inspired in part by the dilemma between compromising sample size and image quality. The Mesoscale Imaging System™ challenges the traditional notion that there should be a compromise between maximizing image quality while allowing larger tissue samples. This enables researchers to sample whole samples, such as mouse brains, versus traditional “slicing” of samples. Utilizing tissue clearing techniques and developing a unique chamber add on to the Zeiss light sheet microscope, researchers can expand the scope of imaging, from imaging 2 regions to over a thousand regions, simultaneously with the same effort.

3D histology offers a diverse platform for various scientific fields aiding in biopsy analysis, disease prognosis, developing clinical trials and drug development.

Read the full feature on Translucence Biosystems here.

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